The more common selective serotonin re-uptake inhibitors (SSRIs) side effects are quite well known but there are a few rare SSRIs side effects such as cardiovascular side effects. Fluoxetine overdoses can cause sinus tachycardia, myocardial infarction, junctional rhythms and trigeminy. Experts suggest electrocardiographic monitoring in patients with pre-existing heart problems who are taking SSRIs.

Lesser Known SSRIs Side Effects

Discontinuing SSRIs can produce withdrawal symptoms that are indistinguishable from the original illness. SSRIs side effects sometimes take the form of extra pyramidal side effects (EPS) and/or akathisia.

These SSRIs side effects manifestations in patients can depend on factors such as the presence of psychomotor disturbance, a previous history of drug induced akathisia and/or EPS, concurrent antidopaminergic and/or serotonergic therapy, recent monoamine oxidase inhibitor discontinuation, comorbid Parkinson's disease and possibly deficient cytochrome P450 isoenzyme status.


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